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Pfizer therefore decided to market it for erectile dysfunction, rather than for angina. Phase I clinical trials under the direction of Ian Osterloh suggested that the medicine had little result on angina, but that it can induce marked penile erections (Boolell et al 1996). It was initially studied for consume in hypertension (high blood pressure) and angina pectoris (a form of cardiovascular disease). The medicine was patented in 1996, approved for manage in erectile dysfunction by the FDA on March 27, 1998, becoming the first medicine approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year (Kling 1998). Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent studies facility. It soon became a extreme success: annual sales of Viagra in the period 1999-2001 exceeded $1 billion.

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